Second Avenue is located on the East Side of the New York City borough of Manhattan extending from Houston Street at its south end to the Harlem River Drive at 128th Street at its north end. A one-way street, vehicular traffic on Second Avenue runs southbound (downtown) only, except for a one-block segment of the avenue in Harlem. South of Houston Street, the roadway continues as Chrystie Street south to Canal Street.

Harlem River Drive is a 4.20-mile (6.76 km) controlled-access parkway in the New York City borough of Manhattan. It runs along the west bank of the Harlem River from the Triborough Bridge in East Harlem to 10th Avenue in Inwood, where the parkway ends and the road continues northwest as Dyckman Street. South of the Triborough Bridge, the parkway continues toward lower Manhattan as FDR Drive. All of Harlem River Drive is designated New York State Route 907P (NY 907P), an unsigned reference route.