The Second Avenue station is a station on the IND Sixth Avenue Line of the New York City Subway, located at the intersection of Second Avenue and Houston Street on the border between the East Village and the Lower East Side, in Manhattan. It is served by the F train at all times and the <F> train during rush hours in the peak direction.

The IND Sixth Avenue Line is a rapid transit line of the B Division of the New York City Subway in the United States. It runs mainly under Sixth Avenue in Manhattan, and continues south to Brooklyn. The B, D, F, and M trains, which use the Sixth Avenue Line through Midtown Manhattan, are colored orange. The B and D trains use the express tracks, while the F, <F> and M trains use the local tracks.