The Second Battle of Agua Prieta, 1 November 1915, was fought between the forces of Pancho Villa and those of the future President of Mexico, Plutarco Elías Calles, a supporter of Venustiano Carranza, at Agua Prieta, Sonora, as part of the Mexican Revolution. Villa's attack on the town was repulsed by Calles. The battle helped to establish Carranza's control over Mexico and directly led to his becoming, with United States recognition, president. Villa believed that Calles had received tactical and strategic support from the United States since the town is located across the border from Douglas, Arizona and launched his raid on Columbus, New Mexico partly as a reprisal.

Douglas is a city in Cochise County, Arizona, United States that lies in the north-west to south-east running Sulphur Springs Valley. Douglas has a border crossing with Mexico at Agua Prieta and a history of mining.