Second Mesa is a census-designated place (CDP) in Navajo County, Arizona, on the Hopi Reservation, atop the 5,700-foot mesa. As of the 2020 census, the CDP population was 843, spread among three Hopi Indian villages, Musungnuvi, Supawlavi, and Songoopavi. The Hopi Cultural Center is on Second Mesa.

Navajo County is in the northern part of the U.S. state of Arizona. As of the 2020 census, its population was 106,717. The county seat is Holbrook.