The Second Van Agt cabinet was the executive branch of the Dutch Government from 11 September 1981 until 29 May 1982. The cabinet was formed by the christian-democratic Christian Democratic Appeal (CDA), the social-democratic Labour Party (PvdA) and the social-liberal Democrats 66 (D'66) after the election of 1981. The cabinet was a Centre-left grand coalition and had a substantial majority in the House of Representatives with Christian-Democratic Leader Dries van Agt serving as Prime Minister. Former Labour Prime Minister Joop den Uyl the Labour Leader served as Deputy Prime Minister, Minister of Social Affairs and Employment and was given the portfolio of Netherlands Antilles Affars, Progressive-Liberal Leader Jan Terlouw served as Deputy Prime Minister and Minister of Economic Affairs.

Jan Cornelis Terlouw is a retired Dutch politician, physicist and author. A member of the Democrats 66 (D66) party, he served as Deputy Prime Minister of the Netherlands from 1981 to 1982 under Prime Minister Dries van Agt.