The second government of José Antonio Griñán was formed on 7 May 2012 following the latter's election as President of Andalusia by the Parliament of Andalusia on 3 May and his swearing-in on 5 May, as a result of the Socialist Party of Andalusia (PSOE–A) and United Left (IULV–CA) being able to muster a majority of seats in Parliament following the 2012 Andalusian regional election, despite the People's Party (PP) emerging as the largest parliamentary force. It succeeded the first Griñán government and was the Government of Andalusia from 7 May 2012 to 10 September 2013, a total of 491 days, or 1 year, 4 months and 3 days.

The president of the Regional Government of Andalusia or, simply the president of Andalusia, is the premier of the devolved government of the Spanish autonomous community of Andalusia. The presidency is one of the three branches of the Regional Government of Andalusia (Junta de Andalucía), the institution whereby the government of the community is organized. The other two branches of are the Parliament of Andalusia and the Council of Government.