Second Lady or Second Gentleman of India is the title given to the host of Uparashtrapati Bhavan, usually the spouse of the vice president. The current second lady of India is Dr. Sudesh Dhankhar, the spouse of the incumbent vice president, Jagdeep Dhankhar.

The vice president of India is the deputy to the head of state of the Republic of India, i.e. the president of India. The office of vice president is the second-highest constitutional office after the president and ranks second in the order of precedence and first in the line of succession to the presidency. The vice president is also the ex officio chairman of the Rajya Sabha.