The Mexican Secretariat for Home Affairs is the public department concerned with the country's domestic affairs, the presenting of the president's bills to Congress, their publication on the Official Journal of the Federation, and certain issues of national security. The country's principal intelligence agency, CISEN, is directly answerable to the Secretary of the Interior. The Secretary is a member of the President's Cabinet and is, given the constitutional implications of the post, the most important Cabinet Member. Additionally, in case of absolute absence of the President, the Secretary of Interior assumes the executive powers of the President provisionally. The Office is practically equivalent to Ministries of the Interior in most other countries and is occasionally translated to English as Ministry, Secretariat or Department of the Interior.

The Cabinet of Mexico is the Executive Cabinet and is a part of the executive branch of the Mexican government. It consists of nineteen Secretaries of State and the Legal Counsel of the Federal Executive.