The secretary of state for science, innovation and technology is a secretary of state in the government of the United Kingdom, with responsibility for the Department for Science, Innovation and Technology. The incumbent is a member of the Cabinet of the United Kingdom.

His Majesty's principal secretaries of state, or secretaries of state, are senior ministers of the Crown in the Government of the United Kingdom. Secretaries of state head most major government departments and make up the majority of the Cabinet of the United Kingdom.