The secretary of state for Wales, also referred to as the Welsh secretary, is a secretary of state in the Government of the United Kingdom, with responsibility for the Wales Office. The incumbent is a member of the Cabinet of the United Kingdom.

His Majesty's principal secretaries of state, or secretaries of state, are senior ministers of the Crown in the Government of the United Kingdom. Secretaries of state head most major government departments and make up the majority of the Cabinet of the United Kingdom.