Sefton railway station is located on the Main Southern line, serving the Sydney suburb of Sefton. The station is heritage-listed in the state heritage register for New South Wales. It is served by Sydney Trains T3 Bankstown line services.

The Main Southern Railway is a major railway in New South Wales, Australia. It runs from Sydney to Albury, near the Victorian border. The line passes through the Southern Highlands, Southern Tablelands, South West Slopes and Riverina regions.