Seiling is a city in Dewey County, Oklahoma, United States. The population was 850 at the 2020 census. The town was named in 1899 for Louis Seiling, a local store owner who had acquired a homestead in the Cheyenne-Arapaho land run of April 1892. The Hobson Town and Improvement Company established a town called Hobson, but the name was changed to Seiling in January 1899. It incorporated in 1909. Seiling is now the largest city in Dewey County. Their girls basketball team has also won the Oklahoma State Championship four times in a row (2016-2019).

U.S. Route 281 (US 281) is a north–south United States Numbered Highway. At 1,875 miles (3,018 km) it is the longest continuous three-digit U.S. Route.