Seiling is a city in Dewey County, Oklahoma, United States. The population was 850 at the 2020 census. The town was named in 1899 for Louis Seiling, a local store owner who had acquired a homestead in the Cheyenne-Arapaho land run of April 1892. The Hobson Town and Improvement Company established a town called Hobson, but the name was changed to Seiling in January 1899. It incorporated in 1909. Seiling is now the largest city in Dewey County. Their girls basketball team has also won the Oklahoma State Championship four times in a row (2016-2019).

U.S. Route 60 (US-60) is a transcontinental U.S. highway extending from near Brenda, Arizona to Virginia Beach, Virginia on the Atlantic Ocean. Along the way, 352.39 miles (567.12 km) of the route lies within the state of Oklahoma. The highway crosses into the state from Texas west of Arnett and serves many towns and cities in the northern part of the state, including Arnett, Seiling, Fairview, Enid, Ponca City, Pawhuska, Bartlesville, and Vinita. US-60 exits Oklahoma near Seneca, Missouri. In Oklahoma, US-60 has three business routes, serving Tonkawa, Ponca City, and Seneca. The first 60.2 miles (96.9 km) of the route, from the Texas line to Seiling, is also designated as State Highway 51 (SH-51).