Sekihoku Main Line is a railway line in Hokkaido, Japan, operated by Hokkaido Railway Company between Shin-Asahikawa in Asahikawa and Abashiri Station in Abashiri. The name comes from the first Kanji characters of Ishikari Province (石狩国) and Kitami Province (北見国), names of ancient provinces along the line.

The Hokkaido Railway Company is one of the constituent companies of the Japan Railways Group, and is often referred to using its official abbreviation of JR Hokkaido . It operates intercity and local rail services in Hokkaido, Japan. The company introduced Kitaca, a smart card ticketing system, in autumn 2008.