Sellers Mansion was a historic Victorian-era home located in Baltimore, Maryland, United States. It was a large three-story Italianate / Second Empire style brick structure located on Lafayette Square in the Harlem Park neighborhood. It was the birthplace and primary residence of aviation pioneer Matthew Bacon Sellers Jr. until 1918, and the headquarters of the community initiative Operation CHAMP from 1967 to 1980. By the early 1990s, the mansion became vacant and was deteriorating. It was listed on the U.S. National Register of Historic Places in 2001, plans for restoration never came to fruition. It was demolished by the city in 2023, after an unexplained fire.

Baltimore City Landmark is a historic property designation made by the city of Baltimore, Maryland. Nominations are reviewed by the city's Commission for Historical & Architectural Preservation (CHAP) and planning board, and are passed by Baltimore City Council. The landmarks program was created in 1971.