Seminex is the widely used abbreviation for Concordia Seminary in Exile, which existed from 1974 to 1987 after a schism in the Lutheran Church–Missouri Synod (LCMS). The seminary in exile was formed due to the ongoing Fundamentalist–Modernist Controversy that was dividing Protestant churches in the United States. At issue were foundational disagreements on the authority of Scripture and the role of Christianity. During the 1960s, many clergy and members of the LCMS grew concerned about the direction of education at their flagship seminary, Concordia Seminary, in St. Louis, Missouri. Professors at Concordia Seminary had, in the 1950s and 1960s, begun to utilize the historical-critical method to analyze the Bible rather than the traditional historical-grammatical method that considered scripture to be the inerrant Word of God.

The Lutheran Church – Missouri Synod (LCMS), also known as the Missouri Synod, is an orthodox, traditional, confessional Lutheran denomination in the United States. With 1.8 million members as of 2021, it is the second-largest Lutheran body in the United States, behind the Evangelical Lutheran Church in America. The LCMS was organized in 1847 at a meeting in Chicago, Illinois, as the German Evangelical Lutheran Synod of Missouri, Ohio, and Other States, a name which partially reflected the geographic locations of the founding congregations.