The gens Sempronia was one of the most ancient and noble houses of ancient Rome. Although the oldest branch of this gens was patrician, with Aulus Sempronius Atratinus obtaining the consulship in 497 BC, the thirteenth year of the Republic, but from the time of the Samnite Wars onward, most if not all of the Sempronii appearing in history were plebeians. Although the Sempronii were illustrious under the Republic, few of them attained any importance or notice in imperial times.

The patricians were originally a group of ruling class families in ancient Rome. The distinction was highly significant in the Roman Kingdom and the early Republic, but its relevance waned after the Conflict of the Orders. By the time of the late Republic and Empire, membership in the patriciate was of only nominal significance. The social structure of ancient Rome revolved around the distinction between the patricians and the plebeians. The status of patricians gave them more political power than the plebeians, but the relationship between the groups eventually caused the Conflict of the Orders. This time period resulted in changing of the social structure of ancient Rome.