Senai–Desaru Expressway, SDE Senai–Desaru Expressway, is an expressway in Johor, Malaysia. It connects Senai in central Johor to Desaru in eastern Johor. Measuring a total length of 77 km (48 mi), it is the third east–west-oriented expressway in the Iskandar Malaysia area after the Pasir Gudang Highway and the Pontian–Johor Bahru Link of the Second Link Expressway. With a new crossing over the Johor River, when opened on 10 June 2011, the expressway shortened travel time from Senai to Desaru from 2.5 hours to one hour.

The Malaysian Expressway System is a network of national controlled-access expressways in Malaysia that forms the primary backbone network of Malaysian national highways. The network begins with the Tanjung Malim–Slim River tolled road which was opened to traffic on 16 March 1966, later North–South Expressway (NSE), and is being substantially developed. Malaysian expressways are built by private companies under the supervision of the government highway authority, Malaysian Highway Authority.