The Senate Republican Conference is the formal organization of the Republican Senators in the United States Senate, who currently number 49. Over the last century, the mission of the conference has expanded and been shaped as a means of informing the media of the opinions and activities of Senate Republicans. Today the Senate Republican Conference assists Republican Senators by providing a full range of communications services including graphics, radio, television, and the Internet. Its current Chairman is Senator John Barrasso, and its Vice Chairwoman is currently Senator Shelley Moore Capito.

John Anthony Barrasso III is an American physician and politician serving as the senior United States senator from Wyoming, a seat he has held since 2007. A member of the Republican Party, he served in the Wyoming State Senate from 2003 to 2007. As Chair of the Senate Republican Conference since 2019, he is the third-ranking Senate Republican.