The Senate of the Republic, or simply the Senate, is the upper house of the bicameral Italian Parliament, the lower house being the Chamber of Deputies. The two houses together form a perfect bicameral system, meaning they perform identical functions, but do so separately. Pursuant to the Articles 57, 58, and 59 of the Italian Constitution, the Senate has 200 elective members, of which 196 are elected from Italian constituencies, and 4 from Italian citizens living abroad. Furthermore, there is a small number of senators for life, either appointed or ex officio. It was established in its current form on 8 May 1948, but previously existed during the Kingdom of Italy as Senato del Regno, itself a continuation of the Senato Subalpino of Sardinia established on 8 May 1848. Members of the Senate are styled Senator or The Honourable Senator and they meet at Palazzo Madama, Rome.

An upper house is one of two chambers of a bicameral legislature, the other chamber being the lower house. The house formally designated as the upper house is usually smaller and often has more restricted power than the lower house. A legislature composed of only one house is described as unicameral.