Seneca County is a county located in the northwestern part of the U.S. state of Ohio. As of the 2020 census, the population was 55,069. Its county seat is Tiffin. The county was created in 1820 and organized in 1824. It is named for the Seneca Indians, the westernmost nation of the Iroquois Confederacy. This people were based in present-day New York but had territory extending into Pennsylvania and Ohio. Seneca County comprises the Tiffin, OH Micropolitan Statistical Area, which is also included in the Findlay–Tiffin, OH Combined Statistical Area.

Northwest Ohio, or Northwestern Ohio, consists of multiple counties in the northwestern corner of the US state of Ohio. This area borders Lake Erie, Southeast Michigan, and northeastern Indiana. Some areas are also considered the Black Swamp area. The Toledo metropolitan area is part of the region.