Senegal participated at the 2010 Winter Olympics in Vancouver, British Columbia, Canada. The country's participation at the Games marked its fifth at the Winter Olympic Games. As in 2006 Olympics, Senegal's sole athlete was Leyti Seck, an alpine skier. He was also the nation's flag bearer in the Parade of Nations. Seck did not win any medals, although he finished ahead of fellow African Samir Azzimani of Morocco in the giant slalom.

Alpine skiing at the 2010 Winter Olympics was held in Canada at Whistler Creekside in Whistler, British Columbia, north of Vancouver. The ten events were scheduled for 13–27 February; weather delayed the first event, the men's downhill, two days until Monday, 15 February.