Senglea Athletic Football Club is a professional Maltese football club based in Senglea. Founded in 1943, the club currently plays in the Maltese Challenge League.

Senglea, also known by its title Città Invicta, is a fortified city in the South Eastern Region of Malta. It is one of the Three Cities in the Grand Harbour area, the other two being Cospicua and Vittoriosa, and has a population of approximately 2,720 people. The city's title Città Invicta was given because it managed to resist the Ottoman invasion at the Great Siege of Malta in 1565. The name Senglea comes from the Grand Master who built it Claude de la Sengle and gave the city a part of his name. While Senglea is the 52nd most populated locality on the island, due to its incredibly small land area, it is the 2nd most densely populated locality after Sliema.