Sentara Norfolk General Hospital (SNGH) is a large academic hospital, which serves as the primary teaching institution for the adjacent Eastern Virginia Medical School. Located in Norfolk, Virginia, in the Ghent neighborhood and adjacent to Downtown, the hospital serves as the Hampton Roads region's only Level I trauma center. The hospital is interconnected to the [[Sentara Heart Hospital; however, it is considered a separate institution. Together with the adjacent Children's Hospital of the King's Daughters, Eastern Virginia Medical School and the Norfolk Department of Health, the Eastern Virginia Medical Center is the largest conglomerate center for health in Hampton Roads. For a time, the U.S. News & World Report rated it the best in Virginia. In 2016, SNGH is tied with VCU Medical Center ranked as #2 while University of Virginia Health System ranked first.

Children's Hospital of The King's Daughters (CHKD), located in Norfolk, Virginia, United States, is the only freestanding children's hospital in Virginia. The hospital treats infants, children, teens, and young adults aged 0–21 and even some adults who require pediatric care.