The separation of Panama from Colombia was formalized on 3 November 1903, with the establishment of the Republic of Panama. From the Independence of Panama from Spain in 1821, Panama had simultaneously declared independence from Spain and joined itself to the confederation of Gran Colombia through the Independence Act of Panama. Panama was always tenuously connected to the rest of the country to the south, owing to its remoteness from the government in Bogotá and lack of a practical overland connection to the rest of Gran Colombia. In 1840–41, a short-lived independent republic was established under Tomás de Herrera. After rejoining Colombia following a 13-month independence, it remained a province which saw frequent rebellious flare-ups, notably the Panama crisis of 1885, which saw the intervention of the United States Navy, and a reaction by the Chilean Navy.

Panama, officially the Republic of Panama, is a country in Latin America at the southern end of Central America, bordering South America. It is bordered by Costa Rica to the west, Colombia to the southeast, the Caribbean Sea to the north, and the Pacific Ocean to the south. Its capital and largest city is Panama City, whose metropolitan area is home to nearly half the country's over 4 million inhabitants.