The September 1503 papal conclave elected Pope Pius III to succeed Pope Alexander VI. Due to the Italian Wars, the College of Cardinals was surrounded by three potentially hostile armies, loyal to Louis XII of France, Ferdinand II of Aragon, and Cesare Borgia.

Cesare Borgia was a Spanish-Italian cardinal and condottiero, an illegitimate son of Pope Alexander VI and member of the Spanish-Aragonese House of Borgia. His fight for power was a major inspiration for The Prince by Niccolò Machiavelli.