Sepulveda Boulevard is a major street and transportation corridor in the City of Los Angeles and several other cities in western Los Angeles County, California. The street parallels Interstate 405 for much of its route. Portions of Sepulveda Boulevard between Manhattan Beach and Los Angeles International Airport (LAX) are designated as part of State Route 1.

Interstate 405 is a major north–south auxiliary Interstate Highway in Southern California. The entire route is known as the northern segment of the San Diego Freeway. I-405 is a bypass auxiliary route of I-5, running along the southern and western parts of the Greater Los Angeles urban area from Irvine in the south to Sylmar in the north.