Sepulveda Boulevard is a major street and transportation corridor in the City of Los Angeles and several other cities in western Los Angeles County, California. The street parallels Interstate 405 for much of its route. Portions of Sepulveda Boulevard between Manhattan Beach and Los Angeles International Airport (LAX) are designated as part of State Route 1.

Route 110, consisting of State Route 110 (SR 110) and Interstate 110 (I-110), is a state and auxiliary Interstate Highway in the Los Angeles metropolitan area of the US state of California. The entire route connects San Pedro and the Port of Los Angeles with Downtown Los Angeles and Pasadena. The southern segment from San Pedro to I-10 in downtown Los Angeles is signed as I-110, while the northern segment to Pasadena is signed as SR 110. The entire length of I-110, as well as SR 110 south of the Four Level Interchange with US Route 101 (US 101), is the Harbor Freeway, and SR 110 north from US 101 to Pasadena is the historic Arroyo Seco Parkway, the first freeway in the western United States.