Seram is the largest and main island of Maluku province of Indonesia, despite Ambon Island's historical importance. It is located just north of the smaller Ambon Island and a few other adjacent islands, such as Saparua, Haruku, Nusa Laut and the Banda Islands.

Maluku is a province of Indonesia. It comprises the central and southern regions of the Maluku Islands. The largest city and capital of Maluku province is Ambon on the small Ambon Island. It is directly adjacent to North Maluku, Southwest Papua, and West Papua in the north, Central Sulawesi, and Southeast Sulawesi in the west, Banda Sea, Australia, East Timor and East Nusa Tenggara in the south and Arafura Sea, Central Papua and South Papua in the east. The land area is 57803.81 km2, and the total population of this province at the 2010 census was 1,533,506 people, rising to 1,848,923 at the 2020 census, the official estimate as at mid 2023 was 1,908,753. Maluku is located in Eastern Indonesia.