The Serb uprising of 1596–1597, also known as the Herzegovina uprising of 1596–1597, was a rebellion organized by Serbian Patriarch Jovan Kantul and led by Grdan, the vojvoda ("duke") of Nikšić against the Ottomans in the Sanjak of Herzegovina and Montenegro Vilayet, during the Long Turkish War (1593–1606). The uprising broke out in the aftermath of the failed Banat Uprising in 1594 and the burning of Saint Sava's relics on 27 April 1595; it included the tribes of Bjelopavlići, Drobnjaci, Nikšić, and Piva. The rebels, defeated at the field of Gacko in 1597, were forced to capitulate due to a lack of foreign support.

The Uprising in Banat was a rebellion organized and led by Serbian Orthodox bishop Teodor of Vršac and Sava Temišvarac against the Ottomans in the Eyalet of Temeşvar. The uprising broke out in 1594, in the initial stage of the Long Turkish War, and was fought by local Serbs, numbering some 5,000, who managed to quickly take over several towns in the region before being crushed by the Ottoman army. The relics of Saint Sava were burnt by the Ottomans as a retaliation. Although short-lived, it inspired future rebellions.