Serendipity 3, often written Serendipity III, is a restaurant located at 225 East 60th Street, between Second and Third avenues in New York City, founded by Calvin L Holt, Patch Caradine and Stephen Bruce in 1954. It also served as a boutique that sold one-of-a-kind fashion and artistic items and hosted famous artists and popular culture figures. The restaurant has been the scene of several films, including the 2001 romantic comedy Serendipity. American singer and actress Selena Gomez has an ownership stake in the restaurant.

Serendipity is a 2001 American romantic comedy film directed by Peter Chelsom, written by Marc Klein, and starring John Cusack and Kate Beckinsale. The film grossed $77.5 million on a $28 million budget.