Seth Edmund Ward was a trader on the California, Oregon and Santa Fe trails who parlayed his success into a real estate empire, some of which is part of today's Country Club District in Kansas City, Missouri.

William Wells Bent was a frontier trader and rancher in the American West, with forts in Colorado. He also acted as a mediator among the Cheyenne Nation, other Native American tribes and the expanding United States. With his brothers, Bent established a trade business along the Santa Fe Trail. In the early 1830s Bent built an adobe fort, called Bent's Fort, along the Arkansas River in present-day Colorado. Furs, horses and other goods were traded for food and other household goods by travelers along the Santa Fe trail, fur-trappers, and local Mexican and Native American people. Bent negotiated a peace among the many Plains tribes north and south of the Arkansas River, as well as between the Native American and the United States government.