The Seto Inland Sea , sometimes shortened to the Inland Sea, is the body of water separating Honshu, Shikoku, and Kyushu, three of the four main islands of Japan. It serves as a waterway connecting the Pacific Ocean to the Sea of Japan. It connects to Osaka Bay and provides a sea transport link to industrial centers in the Kansai region, including Osaka and Kobe. Before the construction of the San'yō Main Line, it was the main transportation link between Kansai and Kyūshū.

Osaka is a designated city in the Kansai region of Honshu in Japan, and one of the three major cities of Japan (Tokyo-Osaka-Nagoya). It is the capital of and most populous city in Osaka Prefecture, and the third-most populous city in Japan, following the special wards of Tokyo and Yokohama. With a population of 2.7 million in the 2020 census, it is also the largest component of the Keihanshin Metropolitan Area, which is the second-largest metropolitan area in Japan and the 10th-largest urban area in the world with more than 19 million inhabitants.