Seton Keough High School was an all-girls college preparatory private, Roman Catholic high school in Baltimore, Maryland. It is located in the Roman Catholic Archdiocese of Baltimore, at 1201 Caton Avenue. It was founded in 1988 after the joining of the two schools, Archbishop Keough High School and Seton High School. The school closed in June 2017.

The Metropolitan Archdiocese of Baltimore is the archdiocese of the Latin Church of the Catholic Church in northern and Western Maryland in the United States. It is the metropolitan see of the Ecclesiastical Province of Baltimore.