As the home of the Pope and the Catholic curia, as well as the locus of many sites and relics of veneration related to apostles, saints and Christian martyrs, Rome had long been a destination for pilgrims. The Via Francigena was an ancient pilgrim route between England and Rome. It was customary to end the pilgrimage with a visit to the tombs of Saints Peter and Paul. Periodically, some were moved to travel to Rome for the spiritual benefits accrued during a Jubilee. These indulgences sometimes required a visit to a specific church or churches. Pilgrims need not visit each church.

The Papal Basilica of Saint Peter in the Vatican, or simply Saint Peter's Basilica, is a church of the Italian High Renaissance located in Vatican City, an independent microstate enclaved within the city of Rome, Italy. It was initially planned in the 15th century by Pope Nicholas V and then Pope Julius II to replace the ageing Old St. Peter's Basilica, which was built in the fourth century by Roman emperor Constantine the Great. Construction of the present basilica began on 18 April 1506 and was completed on 18 November 1626.