Sewanee is a census-designated place (CDP) in Franklin County, Tennessee, United States. The population was 2,535 at the 2020 census. It is part of the Tullahoma, Tennessee Micropolitan Statistical Area.

The University of the South, familiarly known as Sewanee, is a private Episcopal liberal arts college in Sewanee, Tennessee. It is owned by 28 southern dioceses of the Episcopal Church, and its School of Theology is an official seminary of the church. The university's School of Letters offers graduate degrees in American Literature and Creative Writing. The campus consists of 13,000 acres (53 km2) of scenic mountain property atop the Cumberland Plateau, with the developed portion occupying about 1,000 acres (4.0 km2).