Seymour is a city in southeastern Webster County, Missouri, United States. The population was 1,921 at the 2010 census. It is part of the Springfield, Missouri Metropolitan Statistical Area.

Webster County is a county located in the U.S. state of Missouri. As of the 2020 census, the population was 39,085. Its county seat is Marshfield. The county was organized in 1855 and named for U.S. Senator and U.S. Secretary of State Daniel Webster.