The Shanghai Ghetto, formally known as the Restricted Sector for Stateless Refugees, was an area of approximately one square mile (2.6 km2) in the Hongkou district of Japanese-occupied Shanghai. The area included the community around the Ohel Moshe Synagogue. Shanghai was notable for a long period as the only place in the world that unconditionally offered refuge for Jews escaping from the Nazis. After the Japanese occupied all of Shanghai in 1941, the Japanese army forced about 23,000 of the city's Jewish refugees to be restricted or relocated to the Shanghai Ghetto from 1941 to 1945 by the Proclamation Concerning Restriction of Residence and Business of Stateless Refugees. It was one of the poorest and most crowded areas of the city. Local Jewish families and American Jewish charities aided them with shelter, food, and clothing. The Japanese authorities increasingly stepped up restrictions, surrounded the ghetto with barbed wire, and the local Chinese residents, whose living conditions were often as bad, did not leave. By 21 August 1941, the Japanese government closed Shanghai to Jewish immigration.

Hongkou is a district of Shanghai, forming part of the northern urban core. It has a land area of 23.48 km2 (9.07 sq mi) and a population of 757,498 as of 2020. The district borders Yangpu to the east, Pudong to the southeast, Huangpu to the southwest, Jing'an to the west and Baoshan to the north.