Shaniko is a city located in Wasco County, Oregon, United States, on U.S. Route 97 and about 8 miles (13 km) north of Antelope. The population was 30 at the 2020 census.

Wasco County is one of the 36 counties in the U.S. state of Oregon. As of the 2020 census, the population was 25,213. Its county seat is The Dalles. The county is named for a local tribe of Native Americans, the Wasco, a Chinook tribe who live on the south side of the Columbia River. It is near the Washington state line. Wasco County comprises The Dalles Micropolitan Statistical Area.