Shapur I was the second Sasanian King of Kings of Iran. The precise dating of his reign is disputed, but it is generally agreed that he ruled from 240 to 270, with his father Ardashir I as co-regent until the death of the latter in 242. During his co-regency, he helped his father with the conquest and destruction of the city of Hatra, whose fall was facilitated, according to Islamic tradition, by the actions of his future wife al-Nadirah. Shapur also consolidated and expanded the empire of Ardashir I, waged war against the Roman Empire, and seized its cities of Nisibis and Carrhae while he was advancing as far as Roman Syria. Although he was defeated at the Battle of Resaena in 243 by Roman emperor Gordian III, he was the following year able to win the Battle of Misiche and force the new Roman emperor Philip the Arab to sign a favorable peace treaty that was regarded by the Romans as "a most shameful treaty".

Gordian III was Roman emperor from 238 to 244. At the age of 13, he became the youngest sole emperor of the united Roman Empire. Gordian was the son of Antonia Gordiana and Junius Balbus, who died before 238. Antonia Gordiana was the daughter of Emperor Gordian I and younger sister of Emperor Gordian II. Very little is known of his early life before his acclamation. Gordian had assumed the name of his maternal great grandfather in 238.