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Shawano County, Wisconsin

Shawano County is a county located in the U. S. state of Wisconsin. As of the 2010 census, the population was 41,949, its county seat is Shawano. Shawano County is included in the Shawano, WI Micropolitan Statistical Area, included in the Green Bay-Shawano, WI Combined Statistical Area, its name is from a modified Ojibwa term meaning "southern". A Menominee chief named. Many citizens of Shawano believe the lake and city, were named after Chief Sawanoh. A historical marker placed in 1958 near the lake along Highway 22 states the lake was named as the southern boundary of Chippewa territory. Various historical recordings of the spelling of Shawano include: Sawanoh, Sharuno, Savannah, Savanah... which show the influence of French and English translation. Similar differences in spelling have been seen in the following versions: Mahican/Mahikan/Maikens tribe or Mohecan/Morhican/Mohican tribe, all referring to the same Algonquian-speaking people; the federally recognized Stockbridge-Munsee Community, whose ancestors traditionally lived in the East along the Hudson River Valley, is located in Shawano County.

Their reservation encompasses the towns of Red Springs. The county was created as a separate county in 1853 under the name Shawanaw County. In 1861 it achieved full organization; the county, unlike the city, retained the old spelling until 1864. From the mid-nineteenth century on, the county was settled by European Americans, including many German, Polish immigrants, they developed the county for agriculture. Before that, French-Canadian and British fur traders traveled through the area, trading with the Chippewa and other Native American peoples of the region. According to the U. S. Census Bureau, the county has a total area of 909 square miles, of which 893 square miles is land and 16 square miles is water; the city and county jointly operate the Shawano Municipal Airport, located on Shawano Lake. As of the census of 2000, there were 40,664 people, 15,815 households, 11,149 families residing in the county; the population density was 46 people per square mile. There were 18,317 housing units at an average density of 20 per square mile.

The racial makeup of the county was 91.61% White, 0.22% Black or African American, 6.26% Native American, 0.33% Asian, 0.04% Pacific Islander, 0.31% from other races, 1.22% from two or more races. 1.00 % of the population were Latino of any race. 54.9 % were of 8.1 % Polish ancestry. There were 15,815 households out of which 31.50% had children under the age of 18 living with them, 58.30% were married couples living together, 8.00% had a female householder with no husband present, 29.50% were non-families. 24.90% of all households were made up of individuals and 12.10% had someone living alone, 65 years of age or older. The average household size was 2.51 and the average family size was 3.00. In the county, the population was spread out with 25.70% under the age of 18, 6.90% from 18 to 24, 27.50% from 25 to 44, 23.10% from 45 to 64, 16.80% who were 65 years of age or older. The median age was 38 years. For every 100 females there were 99.80 males. For every 100 females age 18 and over, there were 97.60 males.

In 2017, there were 465 births, giving a general fertility rate of 69.8 births per 1000 women aged 15–44, the 18th highest rate out of all 72 Wisconsin counties. Additionally, there were 16 reported induced abortions performed on women of Shawano County residence in 2017. Marion Shawano In presidential elections, Shawano County has voted Democratic on three occasions since 1960, each time by margins of less than four percent. National Register of Historic Places listings in Shawano County, Wisconsin Commemorative Biographical Record of the Upper Wisconsin Counties of Waupaca, Wood, Lincoln, Vilas and Shawano. Chicago: J. H. Beers, 1895. Shawano County Shawano County map from the Wisconsin Department of Transportation Shawano Country Tourism Shawano County Barns Adorned With Colorful Barn Quilts Video produced by Wisconsin Public Television

Scott Wittman

Scott Wittman is an American director and writer for Broadway and television. Wittman was raised in Nanuet, New York, graduated from Nanuet Senior High School in 1972 and attended Emerson College in Boston for two years before leaving to pursue a career in musical theatre in New York City. While directing a show for a Greenwich Village club he met Marc Shaiman, the two became collaborators and professional partners. While Shaiman wrote for television shows, including Saturday Night Live, Wittman directed concerts for such artists as Bette Midler, Christine Ebersole, Raquel Welch, Dame Edna Everage, Lypsinka, among others. In 2002, Shaiman and Wittman wrote the music and lyrics for the musical Hairspray, which won the Drama Desk Award for Outstanding Lyrics, the Tony Award for Best Original Score, a Grammy Award. In addition to Hairspray, Wittman conceived, wrote lyrics for, directed Martin Short: Fame Becomes Me and conceived and directed Matters of the Heart, a solo concert by Patti LuPone in 2000.

Shaiman and Wittman worked on Catch Me If You Can, a musical adaptation of the 2002 Steven Spielberg film, together with Terrence McNally. The musical opened on Broadway in April 2011, they again worked together on the Chocolate Factory the Musical. In 2011, Hairspray was performed at Nanuet Senior High School. In 2013, Wittman and Marc Shaiman co-wrote the score for Bombshell, a musical about Marilyn Monroe within the context of the NBC television show Smash. A soundtrack was released that same year. Wittman and Shaiman collaborated in 2018 on Mary Poppins Returns where Wittman wrote the lyrics for nine of the tracks listed, he and Shaiman were nominated for the Academy Award for Best Original Song for the song "The Place Where Lost Things Go". Scott Wittman on IMDb

1862 in birding and ornithology

Alfred Newton published A list of the birds of Europe, a translation of the Aves section of Die wirbelthiere Europa's by Johann Heinrich Blasius. South Australian Institute Museum opens with Frederick George Waterhouse as Curator. Graceanna Lewis begins ornithological study at the Philadelphia Academy of Natural Sciences. Ferdinand Stoliczka joins the Geological Survey of India becoming interested in birds two years later. Birds described in 1862 include American herring gull, slaty-backed forest falcon, Principe seedeater, yellow-throated spadebill, Réunion harrier, Wallace's fairywren, Publication of final volume of Monographie des picidées by Alfred Malherbe. Hermann Schlegel begins a vast work of 14 volumes Muséum d'histoire naturelle des Pays-Bas. Ongoing events John Gould The birds of Australia. 1 vol. 81 plates. Richter. Richter John Gould The birds of Asia. 530 plates, Artists: J. Gould, H. C. Richter, W. Hart and J. Wolf. Richter and W. Hart


Phenylacetylglutamine is a product formed by the conjugation of phenylacetate and glutamine. It is a common metabolite, occurring in human urine; the highly-nitrogenous compound most encountered in the human subjects with urea cycle disorders, associated with uremic conditions in the body. These conditions, such as uremia or hyperammonemia, tend to cause high levels of nitrogen in the form of ammonia in the blood. Uremic conditions are a result of defects in enzymes that convert ammonia to urea, the primary nitrogenous waste metabolite in the urea cycle. Phenylacetylglutamine is the primary metabolite of the degradation of phenylacetate when in the presence of glutamine in the liver, it is produced in higher concentrations in the body through the metabolic degradation pathway of the pharmaceutical compounds sodium phenylbutyrate, glycerol phenylbutyrate, sodium phenylacetate, considered more toxic, that are used as treatments for the physiological dysfunction in urea cycling. Phenylbutyrate is beta-oxidized into phenylacetate, conjugated with glutamine in the liver and excreted by the kidney.

Phenylacetylglutamine is the product of uremic conditions that require an alternative pathway to the urea cycle for nitrogen waste removal. This process produces comparable levels of phenylacetylglutamine in urine in relation to urea levels in a properly functioning urea cycle. In 24 hours 80-100% of a dose of phenylbutyrate is excreted in the urine as phenylacetylglutamine; the metabolism and conjugation of phenylacetate with glutamine in the liver involves amino acid acetylation carried out by the enzyme phenylacetyltranferase or glutamine N-acetyl transferase. The enzyme catalyzes the reaction of the substrates phenylacetyl-CoA and L-glutamine to produce CoA and alpha-N-phenylacetyl-L-glutamine and phenylacetic acid; the catalytic enzyme has been isolated in the human liver mitochondria. Furthermore, phenylacetylglutamine has been found in human urine, but not in the excretory material of rats, cats, sheep, or horses. Throughout the metabolic process, phenylacetylglutamine is bound and conjugated by free-plasma in the kidney to remove excess nitrogen through its excretion in the urine.

Elevated levels of nitrogen in the blood increase the amount of glutamine, the primary, non-toxic carrier of ammonia in the blood, within patients with hyperammonemia and inborn errors in urea synthesis. Phenylacetylglutamine levels in the urine serves as a more effective biomarker for the excretion of nitrogenous waste than measures of blood plasma, which fluctuate and are a less effective therapeutic monitor of waste nitrogen levels. A 24-hour metabolic urine test of phenylacetylglutamine provides a non-invasive biomarker of waste nitrogen that most reflects the dose of phenylbutyric acid or glycerol phenylbutyrate used to treat patients with urea-cycle disorders. Phenylacetylglutamine isotopically labeled with 14C serves more broadly to characterize relative rates of cellular reactions and functions as a general, non-invasive biomarker for gluconeogenesis and citric acid cycle intermediates in the liver. High levels of phenylacetylglutamine in the urine following metabolism by the gut microbiota, may indicate early renal decline associated with kidney dysfunction and chronic kidney disease.

In CKD phenylacetylglutamine is considered a uremic toxin, uptaken and retained in the blood after microbial fermentation of certain proteins and amino acids in the gut. Blood serum levels of phenylacetylglutamine in CKD are used as a mortality determinant. Blood plasma levels of phenylacetylglutamine increase with exposure to cigarette smoke, in patients with ischemic heart failure, cardiovascular risk, or hypertension, in the development of renal disease and in patients with type 2 diabetes. Glycerol phenylbutyrate Sodium phenylacetate Sodium phenylbutyrate

Haytham Faour

Haytham Moussa Faour is a Lebanese professional footballer who plays as a defensive midfielder for Lebanese Premier League club Ahed. He is known for his defensive reading of the game. Faour joined Ahed in 2009 and became one of the team's main players, winning the Lebanese Golden Ball in 2015. On 2 October 2013, it was reported that Haytham Faour had signed for Iraqi club Al-Naft on a loan deal worth $140,000. After playing a friendly game for the club, the manager cancelled the transfer as he stated that he was looking for a "more attacking minded midfielder". Faour's debut for the national team came on 17 August 2011 in a friendly against Syria, lost at home 2–3. In December 2018, he was called up for the 2019 AFC Asian Cup squad, he played the first two group stage games, against Saudi Arabia. On 24 July 2019, Faour announced his retirement from international football. Ahed Lebanese Premier League: 2009–10, 2010–11, 2014–15, 2016–17, 2017–18, 2018–19 Lebanese FA Cup: 2017–18, 2018–19 Lebanese Elite Cup: 2010, 2011, 2013, 2015 Lebanese Super Cup: 2011, 2015, 2017, 2018, 2019 AFC Cup: 2019 Awards Lebanese Golden Ball winner: 2014–15 Lebanese Premier League Team of the Season: 2011–12, 2012–13, 2014–15, 2016–17, 2017–18 Haytham Faour at RSSSF Haytham Faour at Soccerway Haytham Faour at Haytham Faour at FA Lebanon Haytham Faour at Lebanon Football Guide

Doug Mansolino

Doug Mansolino is an American former coach in Major League Baseball. As of 2018, he is a field coordinator for the Philadelphia Phillies. Mansolino served as a coach with the Chicago White Sox, Milwaukee Brewers, Detroit Tigers, Houston Astros. On September 30, 2007, it was announced. Mansolino was a manager in Minor League Baseball twice. Mansolino attended Huntington Beach High School played college baseball for Golden West College and the Oral Roberts Golden Eagles, he is an avid collector of antique baseball gloves. During the 2006 season, when the Astros were playing a series in Milwaukee, he found a catcher's mitt from 1903. A son, was a minor league infielder, has managed in the minor leagues. Minor league managerial statistics at Major league coaching statistics at Retrosheet