The Sheboygan River is a river flowing to Lake Michigan in eastern Wisconsin in the United States. It is about 81 mi (130 km) long and enters the lake at the city of Sheboygan. The name of the river is Chippewa in origin, Shawb-wa-way-gun, meaning 'hollow bone', 'noise underground' or 'river disappearing underground'.

Sheboygan is a city in and the county seat of Sheboygan County, Wisconsin, United States. The population was 49,929 at the 2020 census. It is the principal city of the Sheboygan metropolitan area, which has a population of 118,034. The city is located on the western shore of Lake Michigan at the mouth of the Sheboygan River, about 50 miles north of Milwaukee and 64 mi (103 km) south of Green Bay.