Sheikh Khazal rebellion refers to the 1924 Arab separatist uprising by Khazal al-Kabi, the Sheikh of Muhammara, in Iranian Khuzestan. The rebellion was quickly and efficiently suppressed by Reza Shah with minimal casualties, subduing the Bakhtiari tribes allied with Sheikh Khazal and resulting in his surrender and the end of Arab autonomy in Khuzestan.

Khuzestan province is one of the 31 provinces of Iran. Located in the southwest of the country, the province borders Iraq and the Persian Gulf. Its capital is Ahvaz and it covers an area of 63,238 square kilometres (24,416 sq mi). Since 2014, it has been part of Iran's Region 4.