Sheldon Lee Cooper, Ph.D., Sc.D., is a fictional character in the CBS television series The Big Bang Theory and its spinoff series Young Sheldon, portrayed by actors Jim Parsons and Iain Armitage respectively. For his portrayal, Parsons won four Primetime Emmy Awards, a Golden Globe Award, a TCA Award, and two Critics' Choice Television Awards. The character's childhood is the focus of Young Sheldon, in which he grows up in East Texas with his family as a child prodigy.

Mayim Chaya Bialik is an American actress, author and former game show host. From 1991 to 1995, she played the title character of the NBC sitcom Blossom. From 2010 to 2019, she played neuroscientist Amy Farrah Fowler on the CBS sitcom The Big Bang Theory, for which she was nominated four times for the Primetime Emmy Award for Outstanding Supporting Actress in a Comedy Series and won the Critics' Choice Television Award for Best Supporting Actress in a Comedy Series in 2015 and 2017. Bialik shared hosting duties of Jeopardy! with Ken Jennings on a rotating basis between August 2021 and December 2023.