The Shenango River is a principal tributary of the Beaver River, approximately 100 mi (160 km) long, in western Pennsylvania in the United States. It also briefly flows through small portions of northeastern Ohio. Via the Beaver and Ohio Rivers, it is part of the watershed of the Mississippi River.

Farrell is a city in western Mercer County, Pennsylvania, United States, along the Shenango River. The population was 4,258 at the 2020 census. It is part of the Hermitage micropolitan area.