Shepherdsville is a home rule-class city on the Salt River in Bullitt County, Kentucky, in the United States. It is the second largest city and seat of its county, located just south of Louisville. The population was 14,201 during the 2020 U.S. Census.

The Salt River is a 150-mile-long (240 km) river in the U.S. state of Kentucky that drains 2,920 square miles (7,600 km2). It begins near Parksville, Kentucky, rising from the north slope of Persimmon Knob south of KY 300 between Alum Springs and Wilsonville, and ends at the Ohio River near West Point. Taylorsville Lake is formed from the Salt River, and Guist Creek Lake is also in its drainage basin.