Sher Ali Khan was Amir of Afghanistan from 1863 to 1866 and from 1868 until his death in 1879. He was one of the sons of Dost Mohammed Khan, founder of the Barakzai dynasty in Afghanistan.

Emir Dost Mohammad Khan Barakzai, nicknamed the Amir-i Kabir, was the founder of the Barakzai dynasty and one of the prominent rulers of Afghanistan during the First Anglo-Afghan War. With the decline of the Durrani dynasty, he became the Emir of Afghanistan in 1826. An ethnic Pashtun, he belonged to the Barakzai tribe. He was the 11th son of Payendah Khan, chief of the Barakzai Pashtuns, who was killed in 1799 by King Zaman Shah Durrani.