Sherborne Abbey, otherwise the Abbey Church of St Mary the Virgin, is a Church of England church in Sherborne in the English county of Dorset. It has been a Saxon cathedral, a Benedictine abbey church, since 1539, a parish church, it is believed that there was a Celtic Christian church called Lanprobi here as early as AD658 when it was part of the Celtic Kingdom of Dumnonia, Kenwalc or Cenwalh, King of the West Saxons is believed to be one of its founders. When the Saxon Diocese of Sherborne was founded in 705, to relieve pressure from the growing see of Winchester, by King Ine of Wessex, he set Aldhelm as first Bishop of the see of Western Wessex, with his seat at Sherborne. Aldhelm was the first of twenty-seven Bishops of Sherborne; the twentieth bishop was Wulfsige III. In 998 he became its first abbot. In 1075 the bishopric of Sherborne was transferred to Old Sarum, so Sherborne remained an abbey church but was no longer a cathedral; the bishop remained the nominal head of the abbey until 1122, when Roger de Caen, Bishop of Salisbury, made the abbey independent.
Known Abbots include: Wulfsige III, 998. Various properties at Sherborne were bought from the king by Sir John Horsey who sold the abbey to the people of Sherborne, who bought the building to be their parish church, which it still is; the original parish church alongside the abbey was demolished, though the foundations are still visible. In 1550, King Edward VI issued a new charter to the school that had existed at Sherborne since 705, some of the remaining abbey buildings were turned over to it; the Abbey is a Grade I listed building. It has several distinct architectural styles throughout. Saxon features still remain in some parts of the Abbey around the Western door. Roger of Caen demolished most of the Saxon church and replaced it with a much larger, Norman style church; the Lady Chapel and Bishop Robert's Chapel were added in the 13th century in the Early English style, in the 15th century, the choir section was rebuilt in the Perpendicular style, including the fan-vaulting Sherborne is still famous for, the remodelling by William Smyth, under Abbot John Brunyng.
The vaulting is believed to have finished in 1490. During this renovation, a riot in the town caused a fire that damaged much of the renovation, causing delays. Traces of the fire's effects can still be seen in the reddening of the walls under the Tower; the fire and its effects caused the design of the Nave to be altered. Some of the Nave's pillars are Norman piers cased in Perpendicular panelling. St Katherine's Chapel, built in the 14th century, but altered in the 15th, contains examples of early Renaissance classicism architecture The whole building is around 240ft in length and 98ft in width; the North Nave Aisle, sometimes called the'Trinitie' or'Dark' Aisle contains several colours from the 2nd Battalion Dorsetshire Regiment and the Dorsetshire Militia. The South Nave Aisle contains colours of the 1st Battalion Dorsetshire Regiment; the North Choir Aisle contains two tombs, believed to be the tombs of King Æthelbald of Wessex and his brother King Ethelbert of Wessex, elder brothers to Alfred the Great.
Inside the Wykeham chapel is the tomb of his son. Horsey had bought the church after the Dissolution of the Monasteries and sold it to the townspeople. In the Chapel is the plainly marked tomb of the poet Sir Thomas Wyatt; the South Transept contains an impressive baroque memorial to John Digby, 3rd Earl of Bristol, made of marble and designed by John Nost. Additionally there is a memorial to Mary Digby. St Katherine's Chapel contains the 16th century tomb of wife Joan; the Chapel was where Sir Walter Lady Raleigh attended services. The North Aisle contains a memorial to Abbot Clement and an effigy to an unknown Prior, while the South Aisle contains an effigy of Abbot Lawrence of Bradford; the Digby Memorial, situated outside the Abbey, is a memorial to George Digby who provided a lot of funding for renovation work during the 19th century. It was built in 1884 and features statues of St Aldhelm, Bishop Roger of Salisbury, Abbot Bradford and Sir Walter Raleigh; the Abbey's organ, located in the North Transept, was installed in 1856 by [ to some considerable acclaim.
It was rebuilt in 1955 by [ with a remote console in the Crossing and a large specification which included a Tuba. In 1972 John Coulson of Bristol again altered the organ by adding a neo-classically styled ‘Positiv’ in place of the Choir manual, some big mixtures on the Great—including the fancifully named Stieglitz—and increased wind pressures throughout. By 1987 an increasing lack of reliability led to a proposed scheme by Bishops, supported by John Norman, Cecil Clutton and Patrick Moule, favouring a return to the Gray & Davison past by halving the number of stops, returning the console ‘upstairs’ to the front of the case, including a'Chair' section instead of the Positiv in order to try to overcome the difficulties of the position of the organ; this was a bold move, but was hardly in keeping and proved to be musically and mechanically a disappointment. After just over twenty years it was necessary for the organ to be rebuilt again, in 2004/05 Kenneth Tickell changed the tonal quality of the instrument, installed new ranks i
State Route 211 is a 33.1-mile-long S-shaped state highway in the northeastern part of the U. S. state of Georgia. Its routing is within portions of Barrow, and, Hall counties. SR 211 begins at an intersection with US 29/SR 8/SR 316 in Barrow County, it heads north-northeast to an intersection with SR 82. It curves to the west to meet SR northeast of Winder; the two highways run concurrent into Winder. Just after entering town, SR 53 joins the concurrency. A few blocks the three routes intersect SR 82. In the main part of town, SR 211 leaves to the northwest, while SR 11/SR 53 continue to the southwest on N. Broad Street, travels through rural areas until it reaches SR 124, southwest of Braselton. Just after SR 211 is an interchange with Interstate 85. A short distance the route cuts across the northernmost corner of Gwinnett County and intersects SR 347, it heads northwest and curves to the north until it meets SR 53 again. It has a second brief concurrency with it; the road heads northeast until it reaches its northern terminus, an intersection with SR 60/SR 322, southeast of Gainesville.
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SAMIS-ESIC School of Information and Communication was founded in 2001 by the Jesuits on the campus of St. Michael College, Madagascar, devoted to training professional journalists and effective communicators for diverse careers. Sami-ESIC offers master's degrees. A typical graduation will include about 100 students. SAMIS-ESIC prepares professionals with communications skills, including written press, radio and political communication, as well as expertise in information and communication technologies; this area of education was chosen by the Jesuits because of its potential for fostering the democratic process and because of the increasing importance of the web: blogs, multimedia art, social networks, immersive technologies, virtual organizations, portable media, podcasts. Integrated internships. Students spend the first two years on a core curriculum, in the third year choose one of the following ares: Media communication Organizational communication Social communication Computer room Radio studio TV Studio
Biomarkers of aging are biomarkers that could predict functional capacity at some age better than chronological age. Stated another way, biomarkers of aging would give the true "biological age", which may be different from the chronological age. Validated biomarkers of aging would allow for testing interventions to extend lifespan, because changes in the biomarkers would be observable throughout the lifespan of the organism. Although maximum lifespan would be a means of validating biomarkers of aging, it would not be a practical means for long-lived species such as humans because longitudinal studies would take far too much time. Ideally, biomarkers of aging should assay the biological process of aging and not a predisposition to disease, should cause a minimal amount of trauma to assay in the organism, should be reproducibly measurable during a short interval compared to the lifespan of the organism. An assemblage of biomarker data for an organism could be termed its "ageotype". Although graying of hair increases with age, hair graying cannot be called a biomarker of ageing.
Skin wrinkles and other common changes seen with aging are not better indicators of future functionality than chronological age. Biogerontologists have continued efforts to find and validate biomarkers of aging, but success thus far has been limited. Levels of CD4 and CD8 memory T cells and naive T cells have been used to give good predictions of the expected lifespan of middle-aged mice. Advances in big data analysis allowed for the new types of "aging clocks" to be developed; the epigenetic clock is a promising biomarker of aging and can predict human chronological age. Basic blood biochemistry and cell counts can be used to predict the chronological age. Further studies of the hematological clock on the large datasets from South Korean and Eastern European populations demonstrated that biomarkers of aging may be population-specific and predictive of mortality, it is possible to predict the human chronological age using the transcriptomic clock. The recent introduction of low-power and compact sensors, based on micro-electromechanical systems has led to a new breed of the wearable and affordable devices providing unparalleled opportunities for the collecting and cloud-storing personal digitized activity records.
Modern deep machine learning techniques could be used to produce a proof-of-concept digital biomarker of age in the form of all-causes-mortality predictor from a sufficiently large collection of one week long human physical activity streams augmented by the rich clinical data. A new epigenetic mark found in studies of aging cells is the loss of histones. Most of the evidence shows. In aging and dividing yeast MNase-seq showed a loss of nucleosomes of ~50%. Proper histone dosage is important in yeast as shown from the extended lifespans seen in strains that are overexpressing histones. A consequence of histone loss in yeast is the amplification of transcription. In younger cells, genes that are most induced with age have specific chromatin structures, such as fuzzy nuclear positioning, lack of a nuclesome depleted region at the promoter, weak chromatin phasing, a higher frequency of TATA elements, higher occupancy of repressive chromatin factors. In older cells, the same genes nucleosome loss at the promoter is more prevalent which leads to higher transcription of these genes.
This phenomenon is not only seen in yeast, but has been seen in aging worms, during aging of human diploid primary fibroblasts, in senescent human cells. In human primary fibroblasts, reduced synthesis of new histones was seen to be a consequence of shortened telomeres that activate the DNA damage response. Loss of core histones may be a general epigenetic mark of aging across many organisms. In addition to the core histones, H2A, H2B, H3, H4, there are other versions of the histone proteins that can be different in their sequence and are important for regulating chromatin dynamics. Histone H3.3 is a variant of histone H3, incorporated into the genome independent of replication. It is the major form of histone H3 seen in the chromatin of senescent human cells, it appears that excess H3.3 can drive senescence. There are multiple variants of histone 2, the one most notably implicated in aging is macroH2A; the function of macroH2A has been assumed to be transcriptional silencing. Chromatin that contains macroH2A is impervious to ATP-dependent remodeling proteins and to the binding of transcription factors.
Increased acetylation of histones contributes to chromatin taking a more euchromatic state as an organism ages, similar to the increased transcription seen due to the loss of histones. There is a reduction in the levels of H3K56ac during aging and an increase in the levels of H4K16ac. Increased H4K16ac in old yeast cells is associated with the decline in levels of the HDAC Sir2, which can increase the life span when overexpressed. Methylation of histones has been tied to life span regulation in many organisms H3K4me3, an activating mark, H4K27me3, a repressing mark. In C. elegans, the loss of any of the three Trithorax proteins that catalyze the trimethylation of H3K4 such as, WDR-5 and the methyltransferases SET-2 and ASH-2, lowers the levels of H3K4me3 and increases lifespan. Loss of the enzyme that demethylates H3K4me3, RB-2, increases H3K4me3 levels in C. elegans and decreases their life spans. In the rhesus macaque brain prefrontal cortex, H3K4me2 increases at prom
Lynbrook is a train station in Lynbrook, New York at Sunrise Highway and Peninsula Boulevard on the Long Island Rail Road. The station is wheelchair accessible through elevator access. Lynbrook was opened as Pearsall's Corner on October 28, 1867 by the South Side Railroad of Long Island; the name became Pearsall's in April 1875 and Lynbrook in 1893. In 1880 the station became the northern terminus of the New York and Long Beach Railroad, a railroad line, acquired by the LIRR and became the Long Beach Branch in 1886; when the NY&LB was added the station gained the "PT Tower", which controlled the junction with the Montauk Branch until 1910, when Long Beach Branch tracks were extended to Valley Stream station. The station was rebuilt in 1881, electrified on September 8, 1910, remodeled sometime in 1920, only to be razed in 1938 as part of a decades-long grade elimination project along the Montauk and Babylon Branches; the third and current elevated station is 1,113 feet west of its former location and opened on October 18, 1938.
This station has two high-level island platforms. The 12-car north platform, Platform A, is between Tracks 1 and 2 of what the railroad calls the Montauk Branch used by Babylon Branch trains; the 10-car south platform, Platform B, is between Tracks 2 of the Long Beach Branch. There are four tracks until the two branches split east of the station; the station is listed on timetables and maps, as being served by both Long Beach and Babylon Branch trains. Both Long Beach and Babylon Branch trains stop there hourly on an alternating basis during off-peak hours. Peak service is about every 20 minutes or less. Late night service is every two hours. Media related to Lynbrook at Wikimedia Commons Lynbrook – LIRRLynbrook LIRR TimetableLynbrook Station Arrt's Arrchives Lynbrook/Pearsall's Corner Station History 1910 Lynbrook Station post card Station from Google Maps Street View Platforms from Google Maps Street View Waiting Room from Google Maps Street View
This is a list of rivers in the U. S. state of Illinois: Mississippi River Ohio River Lusk Creek Saline River Wabash River Little Wabash River Skillet Fork Elm River Fox River Salt Creek Bonpas Creek Embarras River North Fork Embarras River Little Embarras River Little Vermilion River Vermilion River Middle Fork Vermilion River Salt Fork Vermilion River Saline Branch Boneyard Creek Cache River Cypress Creek Big Muddy River Beaucoup Creek Little Muddy River Casey Creek Marys River Little Marys River Kaskaskia River Shoal Creek West Okaw River Palmer Creek Wood River Illinois River Macoupin Creek Big Sandy Creek La Moine River Sangamon River Salt Creek Spring Creek Sugar Creek Lick Creek Spoon River Mackinaw River Little Mackinaw River Panther Creek Red River Big Bureau Creek Little Vermilion River Vermilion River Rooks Creek Fox River Indian Creek Somonauk Creek Mazon River Des Plaines River DuPage River Salt Creek Addison Creek Buffalo Creek Hickory Creek Kankakee River Rock Creek Iroquois River Henderson Creek Edwards River Rock River Green River Pine Creek Kyte River Leaf River Stillman Creek Kishwaukee River Killbuck Creek South Branch Kishwaukee River Owens Creek East Branch South Branch Kishwaukee River Beaver Creek Piscasaw Creek Mokeler Creek Coon Creek Rush Creek North Branch Kishwaukee River Pecatonica River Sugar River Yellow Creek Plum River Apple River Galena River Sinsinawa River Little Menominee River Menominee River Lake Michigan Waukegan River Chicago River North Branch Chicago River Skokie River South Branch Chicago River Bubbly Creek or South Fork South Branch Chicago River Calumet River Grand Calumet River Little Calumet River Midlothian Creek Thorn Creek Butterfield Creek Addison Creek Apple River Beaucoup Creek Beaver Creek Big Bureau Creek Big Muddy River Boneyard Creek Bonpas Creek Bubbly Creek Buffalo Creek Butterfield Creek Cache River Calumet River Casey Creek known as Casey Fork Chicago River Coon Creek Cypress Creek Des Plaines River DuPage River East Branch South Branch Kishwaukee River Edwards River Elm River Embarras River Fox River, northern Illinois Fox River, southern Illinois Galena River Grand Calumet River Green River Henderson Creek Hickory Creek Illinois River Indian Creek Iroquois River Jackson Creek Kankakee River Kaskaskia River Killbuck Creek Kishwaukee River Kyte River La Moine River Leaf River Lick Creek Little Calumet River Little Embarras River Little Mackinaw River Little Marys River Little Menominee River Little Muddy River Little Vermilion River Little Vermilion River Little Wabash River Lusk Creek Mackinaw River Macoupin Creek Marys River Mazon River Menominee River Middle Fork Vermilion River Mississippi River Mokeler Creek North Branch Chicago River North Branch Kishwaukee River North Fork Embarras River Ohio River Owens Creek Palmer Creek Panther Creek Pecatonica River Pine Creek Piscasaw Creek Plum River Red River Rock Creek Rock River Rush Creek Saline Branch Saline River Salt Creek Salt Creek Salt Creek Salt Fork Vermilion River Sangamon River Shoal Creek Sinsinawa River Skillet Fork Skokie River Somonauk Creek South Branch Chicago River South Branch Kishwaukee River Spoon River Stillman Creek Sugar Creek Sugar River Thorn Creek Vermilion River Vermilion River Wabash River West Okaw River Wood River Yellow Creek List of rivers in the United States Chicago Sanitary and Ship Canal Hennepin Canal Parkway State Park Illinois and Michigan Canal Watersheds of Illinois