The Sheridan-Kalorama Historic District is a neighborhood and historic district located in the northwest quadrant of Washington, D.C. The boundaries of the historic district include Rock Creek Park to the north and west, P Street to the south, and 22nd Street and Florida Avenue to the east. On the southwestern edge of the neighborhood is a stretch of Embassy Row on Massachusetts Avenue. The other neighborhood and historic district that lies to the east of Sheridan-Kalorama is Kalorama Triangle Historic District. The two neighborhoods are divided by Connecticut Avenue. For many years both neighborhoods were geographically connected before the stretch of Connecticut Avenue was installed toward the Taft Bridge. Oftentimes, both neighborhoods are simply called "Kalorama" or "Kalorama Heights".

Northwest is the northwestern quadrant of Washington, D.C., the capital of the United States, and is located north of the National Mall and west of North Capitol Street. It is the largest of the four quadrants of the city, and it includes the central business district, the Federal Triangle, and the museums along the northern side of the National Mall, as well as many of the District's historic neighborhoods.