Sherlock Holmes is a 1916 American silent film starring William Gillette as Arthur Conan Doyle's Sherlock Holmes. Directed by Arthur Berthelet, it was produced by Essanay Studios in Chicago. The screenplay was adapted from the 1899 stage play of the same name, which in turn was based on the stories, "A Scandal in Bohemia," "The Final Problem," and A Study in Scarlet by Arthur Conan Doyle.

William Hooker Gillette was an American actor-manager, playwright, and stage-manager in the late 19th and early 20th centuries. He is best remembered for portraying Sherlock Holmes on stage and in a 1916 silent film.