Shin-Ōsaka Station is a major interchange railway station in Yodogawa-ku, Osaka, Japan. It is the western terminus of the high-speed Tōkaidō Shinkansen line from Tokyo, the eastern terminus of the San'yō Shinkansen and one of the main railway terminals in the north of Osaka. The Shinkansen lines are physically joined, and many trains offer through service.

The Tōkaidō Shinkansen is a Japanese high-speed rail line that is part of the nationwide Shinkansen network. Along with the Sanyo Shinkansen, it forms a continuous high-speed railway through the Taiheiyō Belt, also known as the Tokaido corridor. Opening in 1964, running between Tokyo and Shin-Ōsaka, it is the world's first high-speed rail line, and it remains one of the world's busiest. Since 1987, it has been operated by the Central Japan Railway Company, prior to that by Japanese National Railways (JNR).