Shirburn Castle is a Grade I listed, moated castle located at the village of Shirburn, near Watlington, Oxfordshire. Originally constructed in the fourteenth century, it was renovated and remodelled in the Georgian era by Thomas Parker, the first Earl of Macclesfield who made it his family seat, and altered further in the early nineteenth century. The Earls of Macclesfield remained in residence until 2004, and the castle is still (2022) owned by the Macclesfield family company. It formerly contained an important, early eighteenth century library which, along with valuable paintings, sculptures, and other artifacts including furniture, remained in the ownership of the 9th Earl and were largely dispersed at auction following his departure from the property; notable among these items were George Stubbs's 1768 painting "Brood Mares and Foals", a record setter for the artist at auction in 2010, the Macclesfield Psalter, numerous rare and valuable books, and personal correspondence of Sir Isaac Newton.

Shirburn is a village and civil parish about 6 miles (10 km) south of Thame in Oxfordshire. It contains the Grade I listed, 14th-century Shirburn Castle, along with its surrounding, Grade II listed park, and a parish church, the oldest part of which is from the Norman period. The parish has a high altitude by county standards. Its eastern part is in the Chiltern Hills Area of Outstanding Natural Beauty. Shirburn, the largest civil parish in the district, is forested to the south. A motorway cuts across one edge.